Mechanism of Alkaline Gating in a Pentameric Ion Channel
Emelia Karlsson, Ida Ygland, Anton Jansen, Jeffrey E. Plumley, Erik R. Lindahl, Rebecca J. Howard, Berk Hess
This study uses molecular dynamics and electrophysiology to uncover the mechanism of pH sensing in the bacterial ion channel sTeLIC, identifying key Glu residues involved in alkaline gating.
bioRxiv · Jan 8, 2026 · PreprintBiophysics