Author

Jeffrey N Johnston

Vanderbilt University;Primary ORCID profile (0000-0002-0885-636X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Jeffrey N JohnstoniD1 paper · Vanderbilt University Medical Center;

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Bjorn C Knollmann· 1 shared Jeanne Rumsey· 1 shared Kevin M Johnson· 1 shared Madelaine P Thorpe· 1 shared Rachel D Crouch· 1 shared Tri Q Do· 1 shared Wendell S Akers· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Bjorn C Knollmann

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1 paper

Recent·Most cited

Characterizing the Metabolic Fate and Pharmacokinetics of the RyR2 Inhibitor ent-Verticilide

Tri Q Do, Rachel D Crouch, Madelaine P Thorpe, Kevin M Johnson, Jeanne Rumsey, Jeffrey N Johnston, Bjorn C Knollmann, Wendell S Akers

This study characterizes the in vitro metabolism and in vivo pharmacokinetics of ent-verticilide, showing rapid NADPH-dependent depletion and CYP3A-mediated metabolism with low oral bioavailability.

bioRxiv · Nov 3, 2026 · PreprintPharmacology & Toxicology