PhysiologybioRxivPreprint
RyR2-Mediated Ca2+ Leak Drives Progressive Arrhythmogenic Cardiomyopathy
Jingjing Zheng, Daniela Ponce-Balbuena, Sergio Estrada…·Francisco J. Alvarado
This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.
DOI 10.64898/2026.11.02.763829