Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence
Niharika Patel, Jenna Pirrello, Skylar Lynch, Hailee Patel, Bradley J. Sweeney, Shivam Priya, Tanmay P. Lele, Aki Manninen, Daniel E. Conway
This study identifies α6β4 integrins as initiators of epithelial eversion and shows that increased cell proliferation and anchorage-independence sustain apical-out polarity.
Journal of Cell Science · Jun 10, 2026Peer-reviewedCell Biology