Daniel E. Conway

This paper identifies a reversible conformational change in the desmoplakin hinge domain in response to mechanical force, showing its role in mechanotransduction within desmosomes.

The paper develops a FRET-force biosensor to measure mechanical tension on the nuclear pore complex and finds that nuclear strain, not cytoskeletal forces, primarily drives these forces.

This study identifies α6β4 integrins as initiators of epithelial eversion and shows that increased cell proliferation and anchorage-independence sustain apical-out polarity.

The paper identifies deep nuclear envelope invaginations (DINEs) in epithelial cells, showing they organize chromatin and gene activity in response to mechanical cues like crowding and tissue maturation.

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.