WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12
Tabish Hussain, Kevin G. Sanchez, Jennifer Crayton, Dhurjhoti Saha, Collene R. Jeter, Yue Lu, Martı́n C. Abba, Ryan Seo, Jeffrey L. Noebels, Laura K. Fonken, C. Marcelo Aldaz
This paper describes a mouse model of WWOX P47T mutation that mimics human SCAR12, showing epilepsy, neuroinflammation, and cerebellar degeneration.
bioRxiv · Oct 5, 2022 · PreprintNeuroscience