Yue Lu

This study quantifies cancer stemness in prostate cancer across progression stages, showing its association with therapy resistance, poor survival, and lineage plasticity.

This paper modifies Nab-paclitaxel with receptor binders to improve tumor targeting and reduce toxicity, showing enhanced efficacy in cancer cells and xenograft models.

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

This study validates BCL-2 as a therapeutic target in CRPC by showing its upregulation under AR inhibition and demonstrating efficacy of BCL-2 inhibitors in preclinical and clinical models.

This study identifies halomethanes as potential substrates for HgcAB, suggesting their role in the evolution of mercury methylation through metabolic dehalogenation.

The paper identifies a conserved activated valvular interstitial cell population across species and disease types that drives myxomatous mitral valve degeneration.

This study investigates BCL11A DNA binding mechanisms, epigenetic regulation, and small-molecule effects on its expression in human erythrocyte precursor cells.

The paper identifies a unique DNA-binding domain in CDCA7 that recognizes a CpG dyad in non-B DNA, linking it to DNA methylation specificity in ICF syndrome.

The paper identifies ADA2B's role in maintaining oncogenic gene expression programs in multiple myeloma through epigenetic mechanisms.

This study compares four ChIP-Seq library preparation protocols for three different protein targets, finding that each protocol performs best for specific enrichment patterns and input DNA levels.

This paper describes a mouse model of WWOX P47T mutation that mimics human SCAR12, showing epilepsy, neuroinflammation, and cerebellar degeneration.

This study identifies an RNA binding module in the SWI/SNF complex that is essential for enhancer activation and cell-type specific gene regulation during early development.

This study examines DNA methylation changes and intra-tumor heterogeneity in lung adenocarcinoma progression, finding increased methylation aberrations and immunosuppression in later-stage lesions.