C. Marcelo Aldaz

B-cell-Specific Wwox Deletion Promotes Plasmablastic Tumor Development and Pro-Inflammatory Signatures in a Myeloma Mouse Model

This study shows that deleting Wwox in B cells accelerates tumor development and inflammation in a myeloma mouse model.

Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple Myeloma

This study identifies PRMT1 as a critical survival dependency in multiple myeloma cells, showing that its inhibition reduces cell survival and impairs tumor growth.

Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation

The paper shows partial Wwox loss of function in mice worsens sepsis severity and neuroinflammation.

Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury

This study shows that knocking down WWOX in endothelial cells increases inflammation in ventilator-induced lung injury through zyxin upregulation and MAPK signaling changes.

WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12

This paper describes a mouse model of WWOX P47T mutation that mimics human SCAR12, showing epilepsy, neuroinflammation, and cerebellar degeneration.

Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS

This study shows that cigarette smoke and e-cigarette vapor reduce WWOX expression in lungs, leading to increased ARDS severity in mice.