Martı́n C. Abba

Kaposi Sarcoma Herpes Virus Reprograms Mesenchymal Cell Glycosylation to control platelet-derived growth factor receptor A signaling

This paper identifies how KSHV alters mesenchymal cell glycosylation to enhance PDGFRA signaling, contributing to Kaposi sarcoma pathogenesis.

HIV Infection and Opioid Treatment Enable the Engraftment of Kaposi Sarcoma-like Tumors into Immunocompetent Mice

This paper shows that KSHV-infected cells can form tumors in immunocompetent mice when pretreated with EcoHIV and morphine, mimicking human KS lesions.

B-cell-Specific Wwox Deletion Promotes Plasmablastic Tumor Development and Pro-Inflammatory Signatures in a Myeloma Mouse Model

This study shows that deleting Wwox in B cells accelerates tumor development and inflammation in a myeloma mouse model.

SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanism.

This study identifies SPARC as a driver of early breast tumor progression through a TGF-β-dependent mechanism, showing its correlation with MT1-MMP and invasiveness.

COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12

This paper describes a mouse model of WWOX P47T mutation that mimics human SCAR12, showing epilepsy, neuroinflammation, and cerebellar degeneration.