Blockade of mTOR ameliorates IgA Nephropathy by correcting CD89 and CD71 dysfunctions in humanized mice
Alexandra Cambier, Jennifer Da Silva, Julie Bex-Coudrat, Fanny Canesi, Lison Lachize Neanne, Aurélie Sannier, Natacha Patey, Erwan Boedec, Amandine Badie, Renato C. Monteiro
This study shows that blocking mTOR reduces IgA nephropathy in humanized mice by correcting CD89 and CD71 dysfunctions and decreasing immune complex deposits.
PLoS ONE · Oct 7, 2025Peer-reviewedImmunology