A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites
George Maxwell Otto, Akimi Green, Jennifer L. Cabarrus, Francisco Javier Miralles, Parker Torres, Lorenzo E. DeLeon, Jane Chea, Daphnée M. Marciniak, Claude Beltejar, Young V. Kwon, Shao‐En Ong, David M Shechner, Yasemin Sancak
The paper introduces ORCA, a method to isolate mitochondria associated with specific organelles, revealing distinct proteomes and functional roles at organelle contact sites.
bioRxiv · Aug 4, 2026 · PreprintCell Biology