Humoral Immune Dysregulation Defines High-Risk Cirrhotic Ascites
Arielle L. Klepper, Matt S. Zinter, Tamara I. A. Roach, Sukhman Sidhu, Zoe Berman, Ishaan Dureja, Ravi Dandekar, Sammer Ganem, Karina Perlaza, Bryan Castillo-Rojas, Kelsey C. Zorn, Jacquelyn J. Maher, Jody L. Baron, Matthew Yocum, Andrew R. Lai, , Joseph L. DeRisi
The paper analyzes human ascites fluid to identify immune dysregulation features associated with poor outcomes in cirrhosis, finding that B cell dysfunction, not microbial translocation, defines high-risk cases.
bioRxiv · Oct 1, 2026 · PreprintImmunology