Jacquelyn J. Maher

The paper analyzes human ascites fluid to identify immune dysregulation features associated with poor outcomes in cirrhosis, finding that B cell dysfunction, not microbial translocation, defines high-risk cases.

This paper develops an iPSC-based risk predictor for MASLD using lipid accumulation measurements and validates it across three cohorts with varying performance.

This study shows that iPSC-derived hepatocytes from MASLD patients show early mitochondrial dysfunction, including reduced oxygen consumption and increased ROS production, independent of PNPLA3 genotype.

The paper introduces IDLI, a method to map nucleosome structures and distortion patterns in mammalian chromatin, revealing widespread and regulated DNA accessibility across cell types.

This study improves iPSC differentiation into endoderm by using doxycycline to enhance survival via AKT phosphorylation, achieving 90% endoderm formation in over 70 iPSC lines.