Leveraging large-scale multi-omics to identify therapeutic targets from genome-wide association studies
Samuel Lessard, Michael J. Chao, Kadri Reis, Mathieu Beauvais, Deepak K. Rajpal, Srinivas Shankara, Jennifer Sloane, Priit Palta, Katherine Wood Klinger, Emanuele de Rinaldis, Khader Shameer, Clément Chatelain
This study identifies therapeutic targets by integrating GWAS with multi-omics data, finding enriched causal genes and novel associations like IL6ST in polymyalgia rheumatica.
medRxiv · Nov 1, 2023 · PreprintGenetic & Genomic Medicine