Samuel Lessard

RNA Editing of DEGS1 Links Genetic Risk to Ceramide Dysregulation and Astrocyte Toxicity in ALS

The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications

This paper analyzes 100,526 GWAS to identify pleiotropic genes and their therapeutic implications, finding that highly pleiotropic genes are associated with safety liabilities and that combining PAV support with intermediate pleiotropy improves therapeutic success.

Genetic liability to psoriasis predicts severe disease outcomes

This study identifies genetic risk factors associated with severe psoriasis and shows that polygenic risk scores can predict severe disease outcomes better than traditional risk factors.

Multi-omic triangulation identifies molecular candidates of atopic dermatitis severity

This study identifies 440 genes/proteins associated with atopic dermatitis severity through multi-omics analyses and highlights four with significant cross-evidence, including CEP85, which may contribute to severity via impaired phagocytosis.

Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.

This study identifies genetic risk loci and candidate genes for inflammatory polyneuropathy and CIDP through GWAS and functional analyses.

Genome-wide association study analysis of disease severity in acne reveals novel biological insights.

This study conducts a GWAS to analyze acne severity, identifying two new loci and six novel genes associated with severity, while showing limited overlap with known acne risk loci.

Leveraging large-scale multi-omics to identify therapeutic targets from genome-wide association studies

This study identifies therapeutic targets by integrating GWAS with multi-omics data, finding enriched causal genes and novel associations like IL6ST in polymyalgia rheumatica.

Atlas of epistasis

The paper identifies genome-wide significant epistasis interactions across 502 phenotypes using UK Biobank data and replicates some in Finngen consortium cohorts, revealing common variants' roles in complex diseases.

A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in embryonic stem cells

The paper identifies cis- and trans-regulatory elements of Oct4 in mESCs using ctSCAN-SMS, showing CREs are more active and conserved than TREs.