Srinivas Shankara

This study identifies therapeutic targets by integrating GWAS with multi-omics data, finding enriched causal genes and novel associations like IL6ST in polymyalgia rheumatica.

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

The paper identifies a conserved SNCA co-expression module in human brain single-nucleus RNA-seq data and links it to Parkinson's Disease risk loci through protein-protein interaction networks and CRISPR validation.