Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses
Vivian T. Dien, Connor Thompson, Tristin Rammel, Jaime Roquero, Marielle Krivit, Grace Yeo, Daniel J. Honigfort, Pazinah Bhadha, Colin Brown-Greaves, Mariam Dawood, Keerthana Elango, Hyukjin Kwon, Tyler Lopez, Alvin T. Lo, Meghna Manjunath, , Molly Min He
The paper measures RNA, protein, and morphology in NSCLC cells treated with TKIs to identify resistance mechanisms and show that CDK4/6 inhibition enhances TKI efficacy.
bioRxiv · May 6, 2025 · PreprintGenomics