Connor Thompson

Direct In-Sample Sequencing of the 3' Transcriptome Expands the Capabilities of Optical Pooled Screens

The paper introduces a platform that directly sequences 3'UTRs and guide RNAs in fixed cells alongside protein abundance and morphology, enabling CRISPR screening in lung cancer cells.

Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses

The paper measures RNA, protein, and morphology in NSCLC cells treated with TKIs to identify resistance mechanisms and show that CDK4/6 inhibition enhances TKI efficacy.

High-Throughput Multiomics Profiling of Model Systems Using the AVITI24 Platform

The paper introduces a multiomics platform for high-throughput analysis of cellular responses, demonstrating its ability to capture dynamic cellular processes and drug responses in cancer cells.