Age-dependent tumor-immune interactions underlie immunotherapy response in pediatric cancer
Omar Elaskalani, Zahra Abbas, Sébastien Malinge, Merridee A. Wouters, Jenny Truong, Iley M. Johnson, Jorren Kuster, Alexander Nassar, Allison Wan, Hannah Smolders, Hilary L. Hii, Alison M. McDonnell, Isaac Popal, Grace-Alyssa Chua, Vivien L. Nguyen, , Willem Joost Lesterhuis
This study investigates age-dependent tumor-immune interactions in pediatric cancer using mouse models and patient samples, finding that pediatric tumors have distinct immune profiles and poor response to immunotherapy, which can be improved by modulating the tumor microenvironment.
bioRxiv · Jul 16, 2025 · PreprintCancer Biology