Willem Joost Lesterhuis

This study shows copper chelation enhances immune checkpoint blockade therapy in mesothelioma by altering the tumour microenvironment and increasing cytotoxic lymphocytes.

This study investigates age-dependent tumor-immune interactions in pediatric cancer using mouse models and patient samples, finding that pediatric tumors have distinct immune profiles and poor response to immunotherapy, which can be improved by modulating the tumor microenvironment.

CDR-g detects subtle condition-specific gene coexpression changes in single-cell data, identifying novel biological pathways and subpopulations not found by conventional differential expression analysis.