Moremi Bio Agent: Leveraging Agentic Large Language Model for the Discovery of Broad-Spectrum Antibiotics for Enterobacteriaceae
Gertrude Hattoh, Jeremiah Ayensu, Prince Nyarko, Solomon Eshun, Joshua Ntow Opare-Boateng, Osman Tanko, Darlington Akogo
This study uses an agentic LLM to design and evaluate 1,002 broad-spectrum antibiotic candidates targeting Enterobacteriaceae, with 774 passing ADMET benchmarks and 391 showing moderate binding to dual targets.
bioRxiv · Aug 21, 2025 · PreprintBiochemistry