Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders.
Abdul A. Shaik, Praneetha Panthagani, Xiaobo Liu, Stephany Navarro, Jeremy Garza, Monica Aguilera, Jordan Sanchez, Kushal Gupta, Abdul Naji Hamood, Ted Warren Reid, Bruce E. Blough, Elliott Pauli, Jeremy D. Bailoo, Susan E. Bergeson
This paper investigates the molecular mechanisms of BEM, a non-antibiotic minocycline derivative, showing it retains therapeutic pleiotropy while losing antimicrobial activity, making it a potential treatment for neuroimmune and inflammatory disorders.
bioRxiv · Jun 23, 2025 · PreprintPharmacology & Toxicology