Bruce E. Blough

This paper develops AR-12 analogs that show improved host-directed clearance of intracellular Salmonella Typhimurium compared to the parent compound.

The paper screens 343 AR-12 analogs to identify host-directed anti-leishmanial compounds, finding four lead compounds with broad in vitro efficacy and a lysozyme-mediated mechanism.

This paper investigates the molecular mechanisms of BEM, a non-antibiotic minocycline derivative, showing it retains therapeutic pleiotropy while losing antimicrobial activity, making it a potential treatment for neuroimmune and inflammatory disorders.

This study shows that two doses of Qβ virus-like particle-based vaccines generate protective antibodies against heroin and fentanyl in animal models.

This study investigates how mGlu2 and mGlu3 NAMs affect alcohol's interoceptive effects in rats, finding they reduce these effects in both sexes with potential sex differences in response.