Oncogenic reactivation of young L1s is a hallmark of colon cancer
Devin Neu, Stevephen Hung, Cynthia F. Bartels, Zachary J. Faber, Katreya Lovrenert, William Pontius, Laura Morgan, Maharshi Chakraborty, Will Liao, Diana H. Chin, Ellen S. Hong, Jeremy Gray, Victor Rau Moreno, Matthew F. Kalady, Ulrike Peters, , Peter C. Scacheri
The paper identifies oncogenic reactivation of young L1 transposable elements in colon cancer, showing PLZF loss drives this activity independently of cell division.
bioRxiv · May 17, 2023 · PreprintGenomics