Victor Rau Moreno

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention

This study integrates large-scale omics and electronic health records to identify risk proteins and drugs for cancer prevention, finding 101 novel proteins and three drugs associated with reduced colorectal cancer risk.

Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction

The paper introduces pathway-based polygenic risk scores (pPRS) to detect gene-environment interactions, finding a significant interaction between NSAIDs and the TGF-β/GRHR pathway in colorectal cancer.

Multi-Cancer PRS Constellation Model for Cancer Risk Prediction

This paper develops a multi-cancer PRS constellation model integrating genetic and lifestyle factors to predict cancer risk, finding that lifestyle PRSs have limited utility but genetic PRSs remain important.

Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome

This study evaluates the ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome individuals, finding weak associations in specific subgroups.

Oncogenic reactivation of young L1s is a hallmark of colon cancer

The paper identifies oncogenic reactivation of young L1 transposable elements in colon cancer, showing PLZF loss drives this activity independently of cell division.

GCAT|Panel, a comprehensive structural variant haplotype map of the Iberian population from high-coverage whole-genome sequencing

The paper generates a comprehensive haplotype map of the Iberian population using high-coverage whole-genome sequencing, focusing on structural variants and their imputation capabilities.

Germline TYK2 mutation and cancer risk

The paper uses a genetic variant to assess cancer risk associated with TYK2 inhibition, finding increased risks for lung cancer and non-Hodgkin lymphoma.

DNA co-methylation networks outline the structure and remodeling dynamics of colorectal cancer epigenome

The paper analyzes DNA methylation co-variation in colon cancer cohorts to reveal epigenome remodeling dynamics and novel genomic compartments.

Detection of Merkel cell polyomavirus using whole exome sequencing data

The paper presents a bioinformatics method to detect Merkel cell polyomavirus insertions in whole exome sequencing data of Merkel cell carcinoma samples, achieving 100% sensitivity and 62.5% specificity.

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

This study uses Mendelian randomization to show that higher physical activity levels are associated with lower risks of breast and colorectal cancer.

Gut microbiome diversity detected by high-coverage 16S and shotgun sequencing of matched stool and colon biopsy samples