This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Nature Cancer · Jun 23, 2026Peer-reviewedCancer Biology

CpG island density predicts CBP/p300 dependency across 3D chromatin clusters

Md Imdadul H. Khan, Matthew S. Chang, Yaw Asante, Maya Al-Haddad, Teagan Kukhta, Bhavatharini Udhayakumar, Ana María Garzón Porras, Elena-Loredana Rotariu, Saanvi Aneja, Jordyn Kelly, Carrietta Farma-Hai, Kavi Ullal, Diana H. Chin, Alexander J. Federation, Lindsay K. Pino, , Berkley E. Gryder

The paper identifies two classes of Pol2-mediated chromatin clusters and shows CpG island density predicts CBP/p300 dependency.

bioRxiv · May 7, 2026 · PreprintCancer Biology

Dynamic activity of Erg promotes aging of the hematopoietic system

Mayuri Tanaka-Yano, Wade W. Sugden, Dahai Wang, Brianna Badalamenti, Parker Côté, Diana H. Chin, Julia Goldstein, Stephan George, Gabriela Flavia Rodrigues-Luiz, Edroaldo Lummertz da Rocha, Hojun Li, Trista E. North, Berkley E. Gryder, R. Grant Rowe

This study identifies Erg as a master transcription factor whose upregulation during aging is critical for adult hematopoietic stem cell function and resistance to leukemogenesis.

bioRxiv · Jan 23, 2025 · PreprintDevelopmental Biology

Oncogenic reactivation of young L1s is a hallmark of colon cancer

Devin Neu, Stevephen Hung, Cynthia F. Bartels, Zachary J. Faber, Katreya Lovrenert, William Pontius, Laura Morgan, Maharshi Chakraborty, Will Liao, Diana H. Chin, Ellen S. Hong, Jeremy Gray, Victor Rau Moreno, Matthew F. Kalady, Ulrike Peters, , Peter C. Scacheri

The paper identifies oncogenic reactivation of young L1 transposable elements in colon cancer, showing PLZF loss drives this activity independently of cell division.

bioRxiv · May 17, 2023 · PreprintGenomics