Microporous annealed particle scaffolds avoid foreign body response by down regulating complement-fibroblast-macrophage signaling loop
Colleen Roosa, Ethan Nicklow, Jeremy Ortmann, Riley T. Hannan, Jeffrey M. Sturek, Daniel Abebayehu, Donald Griffin
This study compares immune responses to microporous annealed particle scaffolds and nanoporous hydrogels, finding that MAP scaffolds reduce foreign body response by suppressing complement-fibroblast-macrophage signaling.
bioRxiv · Apr 21, 2026 · PreprintBioengineering