Jeffrey M. Sturek

Computational Analysis of Fibroblast Subpopulation Dynamics as a Driver of Fibrotic Foci Formation

This paper develops a multiscale computational model to study how Thy-1 expression in fibroblast subpopulations influences fibrotic foci formation in IPF.

An agent-based model suggests how senescent cell behavior and matrix mechanics drive pulmonary fibrosis in aged mice

The paper develops an agent-based model to show how senescent cell behavior and tissue mechanics contribute to pulmonary fibrosis in aged mice.

Microporous annealed particle scaffolds avoid foreign body response by down regulating complement-fibroblast-macrophage signaling loop

This study compares immune responses to microporous annealed particle scaffolds and nanoporous hydrogels, finding that MAP scaffolds reduce foreign body response by suppressing complement-fibroblast-macrophage signaling.

Respiratory viral infections prime accelerated lung cancer growth

This study shows that prior respiratory viral infections like SARS-CoV-2 or influenza accelerate lung tumor growth by altering the immune environment and promoting a pro-tumor microenvironment.

Lung tissue viscoelasticity is preserved with bleomycin-induced fibrosis in mice

The paper examines lung viscoelasticity in bleomycin-induced fibrosis in mice, finding preserved viscoelastic properties despite increased stiffness.

IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseases.

This study identifies elevated anti-oxidation-specific epitope (OSE) IgA antibodies in fibrotic interstitial lung diseases (fILD) and links them to impaired lung function and a specific B cell subset.

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

Novel wheat germ agglutinin-based mass cytometry cell barcoding reagent for heterogeneous, live or fixed sample

This paper develops a wheat germ agglutinin-based barcode for mass cytometry that works on both live and fixed cells, showing stable yields and no differential performance across PBMC lineages.

A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis

This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.