Nitric oxide-dependent inflammation underlies Notch and PI3K/Akt oncogene cooperation
Santiago Nahuel Villegas, Rita Gombos, Irene Gutiérrez Pérez, Lucia García López, Jesús García-Castillo, Diana Marcela Vallejos, Vanina Da Ros, József Mihály, Maria Dominguez
This study identifies nitric oxide synthase (NOS) and lipoxygenase (LOX) as druggable targets that suppress Notch-PI3K/Akt oncogene cooperation in Drosophila without side effects.
bioRxiv · Aug 9, 2017 · PreprintCancer Biology