Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Emily Kussick, Nelson Johansen, Naz Taskin, Ananya Chowdhury, Meagan A. Quinlan, Alex Fraser, Andrew G. Clark, Brooke Wynalda, Refugio A. Martinez, Erin L Groce, Melissa Reding, Elizabeth Liang, Lyudmila Shulga, Cindy Tzu-Ling Huang, Tamara Casper, , Tanya L. Daigle
The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.
Cell Reports · May 21, 2025Peer-reviewedNeuroscience