Tanya L. Daigle

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

This paper introduces a new system for activating and recording thousands of neurons over a large field-of-view with pixel-level precision.

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

The paper creates a cross-species spinal cord cell type atlas integrating data from mouse, macaque, and human, identifying conserved and species-specific features.

The paper creates a cross-species consensus atlas of primate basal ganglia cell types using multiomic data from human, macaque, and marmoset, identifying 61 conserved cell types and a novel hybrid medium spiny neuron type.

The paper investigates how environmental novelty affects cortical plasticity during navigation using optogenetic stimulation and calcium imaging in mice.

The paper introduces a method to monitor and control neural activity at cellular resolution in mice, discovering new cell types with unique functional properties.

This paper introduces two TEMPO voltage-sensing technologies to image high-frequency neural oscillations in behaving mammals, revealing new insights into excitatory-inhibitory dynamics and wave propagation.

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

The paper evaluates computational methods for predicting cell type-specific enhancers in the mouse cortex using in vivo validation data and finds that open chromatin and sequence models improve prediction accuracy.

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

This study investigates neurogliaform cells in the visual cortex, showing their activity correlates with locomotion and their functional role is influenced by laminar position and connectivity.

The paper investigates traveling spiral waves in the brain, showing they are organized across spatial scales and coordinated with subcortical patterns.

The paper develops AAV-based genetic tools to specifically target astrocytes and oligodendrocytes across species, revealing functional roles in reward-dependent acetylcholine responses.

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

The paper presents a synaptic physiology dataset and analysis platform to study cortical microcircuit structure and synaptic properties in mouse and human neocortex, revealing layer-dependent connectivity and subclass-specific dynamics.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper introduces a multifunctional transgenic mouse line and a pipeline to read and write neural activity patterns with high precision in behaving animals.

The paper shows motion/direction-sensitive thalamic neurons project more to middle layers of V1 than previously thought, challenging existing views on thalamocortical organization.

The paper identifies conserved and divergent morpho-electric and transcriptomic properties of human and rodent layer 5 extratelencephalic-projecting neurons using patch-seq in human brain slices.

The paper characterizes transcriptomic and physiological properties of GABAergic cortical neurons in mice, identifying 20 interneuron met-types with consistent features across modalities.

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

The paper develops enhancer viruses and a transgenic mouse line to enable combinatorial labeling of specific neuronal subclasses in the mouse cortex and human slices.

The paper maps the functional and structural properties of feedforward projections from the LGN to V1 in mice, revealing differences in receptive fields and depth-dependent biases between location-sensitive and motion-sensitive axons.

The paper introduces a light-inducible recombinase system for targeted genomic modifications in neurons, enabling precise labeling and functional analysis of neural circuits in live mouse brains.