Meagan A. Quinlan

Cell type-selective AADC expression reduces motor deficits and dyskinesia in Parkinson's disease mouse models

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.

Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior

This study shows that Kv4.3 and BKCa1.1 ion channels regulate dopamine neuron firing and release on different time scales, influencing distinct phases of reinforced behavior in mice.