Cell BiologyiSciencePeer-reviewed
Opto-controlled C9orf72 poly-PR forms anisotropic condensates causative of TDP-43 pathology in the nucleus
Rachel E. Hodgson, Jessica A. Rayment, Wan-Ping Huang…·Tatyana A. Shelkovnikova
This study uses optogenetics to model C9orf72 poly-PR condensation in cells, revealing anisotropic nuclear condensates that cause TDP-43 pathology without stress response activation.
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