Nrf2 orchestrates epigenetic regulations and serves as the master regulator of KLF4 expression and activity during arsenic-induced transformation
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen
This study shows Nrf2 regulates KLF4 expression and activity in arsenic-exposed cells, promoting cancer stem-like cell formation through epigenetic mechanisms.
Advanced Science · Aug 4, 2025Peer-reviewedCancer Biology