John D. Haley

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

Mdig shapes 3D chromatin architecture of immune checkpoint genes and limits metastasis of triple negative breast cancer cells

This study identifies mdig as a chromatin-topology regulator that suppresses immune-checkpoint activation and metastasis in triple-negative breast cancer by maintaining 3D chromatin architecture.

Fosl2 regulates the transition from parietal epithelial cells to myofibroblasts in the kidney

This study identifies Fosl2 as a regulator of PEC-to-myofibroblast transition in kidney disease using mouse models and human biopsies.

Identifying Modulators of the Post-Antibiotic Effect

This paper identifies genes that enhance the post-antibiotic effect (PAE) in E. coli using a high-throughput screen of deletion strains, revealing that rfaE deletion increases PAE by stabilizing LpxC.

Nrf2 orchestrates epigenetic regulations and serves as the master regulator of KLF4 expression and activity during arsenic-induced transformation

This study shows Nrf2 regulates KLF4 expression and activity in arsenic-exposed cells, promoting cancer stem-like cell formation through epigenetic mechanisms.