Cancer BiologyAdvanced SciencePeer-reviewed
Nrf2 orchestrates epigenetic regulations and serves as the master regulator of KLF4 expression and activity during arsenic-induced transformation
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah…·Fei Chen
This study shows Nrf2 regulates KLF4 expression and activity in arsenic-exposed cells, promoting cancer stem-like cell formation through epigenetic mechanisms.