Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells
Christopher W. Wasson, Sophie L. Dibb, Begoña Caballero-Ruiz, Eva M. Clavane, Rebecca Wells, Vishal Kakkar, Enrico De Lorenzis, Rebecca L. Ross, Jessica Bryon, Emma C. Derrett‐Smith, Christopher Paul Denton, Paul J. Meakin, Francesco Del Galdo
This study shows CLIC4 regulates type 1 interferon signaling in SSc epithelial cells and inhibiting it blocks IFN pathway activation.
bioRxiv · Mar 8, 2024 · PreprintImmunology