Francesco Del Galdo

Chikungunya virus live-cell reporter systems reveal cell-type-dependent antiviral responses to ribavirin

This study develops live-cell CHIKV reporter systems to analyze cell-type-dependent antiviral responses to ribavirin, revealing differences in antiviral efficacy across cell models.

The lncRNA HOTAIR/EZH2 interaction inhibitor AC1Q3QWB (AQB) attenuates fibrotic SSc skin tissue re-modelling

This paper shows that inhibiting the HOTAIR/EZH2 interaction with AQB reduces pro-fibrotic gene expression and tissue remodeling in SSc fibroblasts and skin.

Aurora A kinase activation contributes to the fibrotic phenotype in Systemic Sclerosis through primary cilia shortening

This study identifies AURKA/HDAC6 activation as a driver of primary cilia shortening and fibroblast activation in systemic sclerosis.

Imbalance of Ciliary Programs Drives Fibroblast Differentiation and Fibrotic Signaling in Systemic Sclerosis

This study identifies ciliary program imbalance as a driver of fibroblast-to-myofibroblast reprogramming in systemic sclerosis, suggesting ciliotherapy as a potential treatment.

Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis

This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells

This study shows CLIC4 regulates type 1 interferon signaling in SSc epithelial cells and inhibiting it blocks IFN pathway activation.