Structural basis for HKU5-CoV main protease inhibition by the clinical antivirals nirmatrelvir and ensitrelvir
Hyun Kim, Jinsook Ahn, Juyeon Lee, Seungheon Jung, Ji Woo Kim, Byungil Kim, Nam‐Chul Ha, Inseong Jo
This study determines the crystal structures of HKU5-CoV Mpro with and without inhibitors, revealing conserved binding mechanisms and informing antiviral drug development.
bioRxiv · Jul 2, 2026 · PreprintBiochemistry