BiochemistrybioRxivPreprint
Structural basis for HKU5-CoV main protease inhibition by the clinical antivirals nirmatrelvir and ensitrelvir
Hyun Kim, Jinsook Ahn, Juyeon Lee…·Inseong Jo
This study determines the crystal structures of HKU5-CoV Mpro with and without inhibitors, revealing conserved binding mechanisms and informing antiviral drug development.
DOI 10.64898/2026.06.01.729201