Whole-genome duplication drives biosynthetic gene cluster fragmentation and regulatory rewiring of monoterpene indole alkaloid metabolism in Strychnos
Jiming Liu, Joan Jing Yi Jong, Rami‐Petteri Apuli, Hebi Zhuang, Roy Tham Jun Kai, Abner Herbert Lim, Wei Liu, Jia Jun Ngiam, Matti A. Niissalo, Gillian Su-Wen Khew, Bin Tean Teh, Jarkko Salojärvi
This paper investigates how whole-genome duplication affects biosynthetic gene clusters in Strychnos species, showing that pathway function can persist despite fragmentation and regulatory rewiring.
bioRxiv · Aug 22, 2026 · PreprintEvolutionary Biology