Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation
Sichao Huang, Fengzhen Deng, Te Liu, Wenjian Li, Peiying Wang, Jiahuan Song, Jingjing Huang, Shiyu Zhang, Jiayi Liu, Yan Wang, Manjie Zhang, Bin Sun
This study shows that myristoylation of VP4 enables membrane anchoring, phase separation, and pore formation in enteroviruses through multiple functional roles.
bioRxiv · Oct 7, 2026 · PreprintBiophysics