A rugged binding landscape unifies static and dynamic paradigms in protein-protein interactions
Te Liu, Sichao Huang, Wenhua Li, Peiying Wang, Jiahuan Song, Jiaxin Liu, Manjie Zhang, Bin Sun
This study shows that protein-protein interactions can follow static or dynamic binding paradigms, with distinct temperature dependencies and mechanisms affecting affinity prediction.
bioRxiv · Sep 4, 2026 · PreprintBiophysics