Wenhua Li

This study shows that protein-protein interactions can follow static or dynamic binding paradigms, with distinct temperature dependencies and mechanisms affecting affinity prediction.

This study identifies Slc25a34 as a cold-responsive mitochondrial transporter that facilitates AMP transport to activate thermogenesis in brown adipocytes.

This study analyzes histone modifications H3K4me1 and H3K27ac during maternal-to-zygotic transition in mouse embryos, revealing dynamic reprogramming and enhancer type changes.

This study develops a mouse-derived organoid model of meibomian glands and identifies the Hippo-YAP pathway as critical for gland development and dysfunction.

This study shows that RIPK3 protects photoreceptors in a Stargardt disease mouse model by inhibiting apoptosis rather than necroptosis.

This paper introduces a strategy called TopCare to reduce doxorubicin-induced cardiotoxicity by temporarily increasing P-gp expression in cardiomyocytes, showing improved survival and cardiac function in mice and pigs.