Cell BiologyEMBO Molecular MedicinePeer-reviewed
Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies
Xue Chen, Ying Wang, Jia-Nan Wang…·Qing-Huai Liu
This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.