Endothelial Kallikrein-Related Peptidase 8 Promotes Diabetic Nephropathy through a LIFR dependent mechanism
Jiankui Du, Mingyang Li, Ying Jiang, Zhengshan Tang, Dan‐Hong Xu, Hongling Yin, Jihong Yuan, Xiaoyan Zhu, Xin Ni
This study identifies endothelial KLK8 as a driver of diabetic nephropathy through LIFR-dependent signaling, showing improved DN features in KLK8 knockout mice and correlating KLK8 with disease markers in patients.
bioRxiv · Jul 1, 2025 · PreprintPathology