PathologybioRxivPreprint
Endothelial Kallikrein-Related Peptidase 8 Promotes Diabetic Nephropathy through a LIFR dependent mechanism
Jiankui Du, Mingyang Li, Ying Jiang…·Xin Ni
This study identifies endothelial KLK8 as a driver of diabetic nephropathy through LIFR-dependent signaling, showing improved DN features in KLK8 knockout mice and correlating KLK8 with disease markers in patients.