Inherited defects in natural killer cells shape tumor immune microenvironment, clinical outcome and immunotherapy response
Xue Xu, Jianqiang Li, Jinfeng Zou, Xiaowen Feng, Chao Zhang, Ruiqing Zheng, Weixiang Duanmu, Arnab Saha-Mandal, Zhong Ming, Edwin Wang
The paper identifies inherited defects in NK cells, antigen processing, and Wnt pathways that shape tumor immune microenvironment and clinical outcomes across 13 cancer types.
bioRxiv · Nov 27, 2018 · PreprintCancer Biology