Chao Zhang

Human brain white matter charts in international populations

The paper develops population-specific white matter charts for Chinese and Western populations, showing differences in maturation timing and improved prediction accuracy when using population-matched models.

Alpha Spatial: Language-guided prediction of single-cell spatial gene expression from histology

Alpha Spatial predicts single-cell gene expression from histology using language-guided models, improving accuracy with matched biological context and outperforming existing methods in breast cancer analysis.

Structural Basis for the Rational Design of UAMC-1110-Based FAP Radiopharmaceuticals

This study identifies a stable charge-anchored binding mode for FAP ligands, providing a framework for designing effective radiopharmaceuticals.

Deep-layer cortical tracking abruptly collapses in the absence of language comprehension

The paper tracks cortical computations during speech processing using a language model and MEG, finding comprehension sustains alignment in deep layers while acoustic processing remains unchanged without comprehension.

β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.

Whole-genome phylogenomics and synteny resolve a single origin of body-plan asymmetry in flatfishes

The paper uses whole-genome phylogenomic and synteny data to resolve the evolutionary origin of flatfish body asymmetry, finding strong support for a single origin.

Competition among freshwater clades explains cave colonization in blind cavefishes

The paper uses genomic data to determine whether flatfish asymmetry evolved once or multiple times, finding strong support for a single origin.

Reciprocal adipose-heart regulation of NRAC

The paper investigates NRAC's role in reciprocal adipose-heart regulation of fatty acid metabolism across nutritional states using human and mouse data.

Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

Linkage: an interactive shiny app and R package for linking of DNA regulatory peaks to genes

Linkage is an R Shiny app and package that links ATAC-seq peaks to genes to identify cis-regulatory elements and transcription factor networks.

Trio deep-sequencing does not reveal unexpected mutations in Cas9-edited monkeys

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.

Acidic microenvironment shaped by lactate accumulation promotes pluripotency through multiple mechanisms

This study shows that an acidic microenvironment, caused by lactate accumulation, promotes pluripotency in mouse and human ESCs through multiple mechanisms involving histone modification, mRNA stability, and microRNA regulation.

Reconciling the clk-1 and aging paradox and categorizing lifespan curves by taking individual specificity into account

The paper examines the clk-1 gene's role in aging, showing individual variability in lifespan outcomes and categorizes lifespan curves into five patterns, with clk-1 mutants fitting the flattened pattern.

A logic approach to modeling nomenclatural change

The paper uses Answer Set Programming to model nomenclatural changes in zoology, demonstrating how logic can infer and visualize compliance with nomenclatural rules in various scenarios.