Mechanism study on lactic acid promoting intervertebral disc degeneration by regulating senescence and DNA damage of cartilage endplate stem cells
Qiao Lv, Tianling Wang, Lu Jiang, Qian Chen, Jin Peng, Ju Zhou, Qian Min, Yongqi Pu, Jianyun Zhou, Q HUANG
This study shows lactic acid promotes intervertebral disc degeneration by causing stem cell senescence and DNA damage through oxidative stress and cell cycle arrest.
bioRxiv · Jan 25, 2026 · PreprintCell Biology